We have previously shown that sorafenib, a multikinase inhibitor, exhibits cytotoxic effects on c. Vaccination of HER2NEU transgenic mice, a mouse breast cancer model that closely mimics the immune modulation and tolerance in some breast cancer patients, with Hp91 loaded PLGA-NPs enhanced the activation of HER2 specific cytotoxic T lymphocyte (CTL) responses, delayed tumor development, and prolonged sur.
#Dendrite growth free
Free peptide did not significantly augment immune responses but, when delivered in poly(D,L-lactic-co-glycolic) acid nanoparticles (PLGA-NPs), robust activation of dendritic cells (DCs) and increased activation of HER2 specific T cells was observed in vitro. In this study, Hp91 was tested as part of a therapeutic vaccine against human epidermal growth factor receptor 2 (HER2) positive breast cancer. We have previously shown that Hp91, a peptide derived from the B box domain in high-mobility group box protein 1 (HMGB1), acts as potent immune adjuvant. more Cancer vaccines have the potential to induce curative anti-tumor immune responses and better adjuvants may improve vaccine efficacy. In addition, in two xenograft mouse models of CLL, on.Ĭancer vaccines have the potential to induce curative anti-tumor immune responses and better adju. NXT629 reduced the number of leukemia cells undergoing cell-division. To mimic the proliferative lymphoid compartment of CLL, we examined the activity of NXT629 on CLL cells that were stimulated to proliferate in vitro. Furthermore, NXT629 induced apoptosis of CLL cells even in the presence of a protective microenvironment. NXT629 inhibited agonist-induced transcription of PPARα regulated genes, demonstrating target engagement in CLL cells. To evaluate PPARα as a potential therapeutic target, we have developed a highly selective, potent small molecule antagonist of PPARα, NXT629.
![dendrite growth dendrite growth](https://n-e-r-v-o-u-s.com/projects/i.php?/000/604/dendrite-diagram,large.1415500725.png)
![dendrite growth dendrite growth](http://eweb.furman.edu/~einstein/general/development/dendrites.jpg)
Peroxisome proliferator-activated receptor alpha (PPARα), a major transcriptional regulator of fatty acid oxidation (FAO), was recently shown to be upregulated in CLL. Our findings implicate a supporting role for fatty acid metabolism in chronic lymphocytic leukemia (CLL) cell survival. more Tumor-specific metabolic changes can reveal new therapeutic targets. Tumor-specific metabolic changes can reveal new therapeutic targets.